According to the multivariate analysis, the independent risk factors for AKI were a history of hypertension (OR 1.44, 95% CI 1.07–1.94; p 0.017), serum creatinine concentration > 1.16 mg/dL (OR 3.54, 95% CI 2.65–4.73; p < 0.001), serum albumin concentration ≤ 2.81 g/dL, APACHE II score > 25 points (OR 2.10, 95% CI 1.56–2.81; p < 0.001) and SAPS 3 score > 68 points (OR 1.75, 95% CI 1.31–2.33; p < 0.001). The gene discussed is ALB; the disease is Hypertension.