Our findings indicated that Rpl10a-deficient zebrafish had reduced hemoglobin levels but increased the expression of tp53. While Torihara et al. (2011) indicated that in Rps19 deficiency, the Tp53-independent pathway is more important for the anemia phenotype, the morphological abnormalities were dependent on Tp53 activation27. Here, TP53 is linked to anemia (phenotype).