Accordingly, we observed a correlation between upregulated miRNAs hsa-miR-200a-3p, −200b-3p, −141-3p and -429 (Table 1, Supplementary Table 1) and their downregulated target gene ZEB1. Moreover, hsa-miR-429 expression was upregulated in human CRC tissues, and high hsa-miR-429 expression was significantly associated with tumor size, lymph node metastasis and poor prognosis42. This evidence concerns the gene ZEB1 and neoplasm.