TAS2R38 SNPs dictate individual differences in PTC/PROP tasting54–56, food linking patterns1,57 and also in TAS2R38‒mediated pathophysiology9, such as susceptibility, severity, and prognosis of upper respiratory infection, chronic rhinosinusitis and biofilm formation in chronic rhinosinusitis patients48,58–64, development of colorectal cancer45,65, taste disorders66 and neurodegenerative diseases49. The gene discussed is TAS2R38; the disease is chronic rhinosinusitis.