However, little is known about whether and to what extent the different types and constellations of TP53 lesions, i.e. a deletion-first (haploinsufficiency) vs. a mutation-first (potential dominant negativity) vs. a double-hit scenario (most often high expression of just mutant p53 protein) may affect p53 system functionality and drug responsiveness in MM, and if such knowledge could inform therapeutic decisions. This evidence concerns the gene TP53 and Miyoshi myopathy.