TP53 and Miyoshi myopathy: Third, these data lend support for the notion that it is indeed the hit to TP53 – and possibly to TP53 only – that represents the oncogenic element in the del17p lesion, and that it is the associated loss of p53 system function (and not any gain-of-function mechanism) that generally drives the spread of TP53 lesions across the MM holotumor.