Likewise, it would be important to know if patients with MM subclones that display single TP53 lesions should preferentially be treated with therapies that are known to work on MM cells with TP53 defects, and if such genetic constellations are an indication for use of powerful combination approaches, perhaps with inclusion of immunotherapies, in an attempt to nip emergent (pre-) high risk clones in the bud. Here, TP53 is linked to Miyoshi myopathy.