SLC6A3 and schizophrenia: Given the important role of DAT in maintaining dopamine homeostasis, the anatomical complexity of the striatum and our recent data showing abundant changes in gene expression in the frontal pole from patients with schizophrenia,22 we decided to measure levels of DAT, using desmethylimipramine-insensitive mazindol-sensitive [3H]mazindol binding and autoradiography, in the frontal pole (BA 10) and the striatum from patients with schizophrenia.