In interpreting our postmortem CNS data, current data suggest that lower levels of DAT would be consistent with the presence of higher levels of extracellular dopamine.12,13 Hence, our findings on DAT could be synergistic with findings suggesting elevated dopamine synthesis capacity in patients with schizophrenia and the conclusion that high levels of dopamine in the striatum in patients with schizophrenia are contributing to the onset of positive symptoms.40 The gene discussed is SLC6A3; the disease is schizophrenia.