IHC studies, combined with Aperio Scanscope-based quantification45–51, revealed significantly higher levels of LRIG1 protein in 12 whole-mount (WM) untreated human PCa (HPCa) specimens (Fig. 1e, f; Supplementary Fig. 4a, b; Supplementary Table 2) compared to matched normal/benign tissues. The gene discussed is LRIG1; the disease is posterior cortical atrophy.