Intriguingly, the ERBB3 mRNA expression pattern in prostate tumors of different Gleason grade was very similar to that of LRIG1 (Fig. 8e; compare with Supplementary Fig. 13a) and, in fact, LRIG1 mRNA levels correlated with those of ERBB3 but not of other ERBB members (Fig. 8f). Here, LRIG1 is linked to prostate neoplasm.