AR and posterior cortical atrophy: On the other hand, as both patient CRPC (Fig. 5a; Supplementary Fig. 13b–d) and experimental CRPC models (Fig. 5c–f) clearly expressed significant levels of LRIG1, we suspected that residual AR binding to ABS2-ABS4 (Fig. 7c) might be involved, at least partially, in mediating LRIG1 transcription in AI PCa cells.