Interrogation of LRIG1 mRNA levels in 31 human cancers in TCGA reveals that LRIG1 is downregulated in bladder, cervical, colon/rectum, and thyroid cancers and melanoma but upregulated in esophageal carcinoma, low-grade glioma and GBM, thymoma, B-cell lymphoma, AML, and PCa, and the trend of LRIG1 upregulation is also observed in several other cancers (Supplementary Fig. 16). Here, LRIG1 is linked to central nervous system cancer.