As LRIG1 is induced by EGF and functions in a feedback loop to dampen the EGF/EGFR and other ERBB and RTK signaling2,15–21, and also because ERBB and AR signaling cross-regulates each other and PCa development and castration resistance70–73, we explored the inter-relationship between AR, LRIG1 and ERBBs in PCa and potential involvement of ERBB members in LRIG1-mediated inhibition of PCa (Figs. 8–10; Supplementary Fig. 15). Here, EGF is linked to posterior cortical atrophy.