Knocking down endogenous LRIG1 in 4 AR+ PCa cells/tumors (i.e., LNCaP, VCaP, LAPC4, and LAPC9) upregulated ERBBs in a model-dependent manner, exemplified by ERBB2 upregulation in 3 models (LNCaP, LAPC4, LAPC9), EGFR increase in VCaP, and ERBB3 increase in LAPC4 (Fig. 9a–d). Here, LRIG1 is linked to posterior cortical atrophy.