Interestingly, unlike AR binding profiles in AD LNCaP cells (Fig. 7e, f), AR primarily bound to the ABS2 and ABS4 with negligible binding to ABS1 in AD LAPC9 cells (Supplementary Fig. 14m), suggesting cell type-dependent AR regulation of LRIG1 in AD PCa cells. This evidence concerns the gene LRIG1 and Alzheimer disease.