Interrogation of LRIG1 mRNA levels in 31 human cancers in TCGA reveals that LRIG1 is downregulated in bladder, cervical, colon/rectum, and thyroid cancers and melanoma but upregulated in esophageal carcinoma, low-grade glioma and GBM, thymoma, B-cell lymphoma, AML, and PCa, and the trend of LRIG1 upregulation is also observed in several other cancers (Supplementary Fig. 16). This evidence concerns the gene LRIG1 and thyroid gland carcinoma.