LRIG1 and prostate neoplasm: This speculation is partially supported by observations that, although AR and ERBB3 (and in some cases, EGFR) mRNA levels are elevated in prostate tumors, at the protein level, there exists a strong inverse correlation between AR and EGFR/pEGFR(pY1173) and a moderate inverse correlation between AR and pERBB3(pY1289), presumably because AR also activates LRIG1 to post-translationally degrades (p)ERBB proteins.