RUNX3 and neoplasm: hnRNPQ also regulates various genes expression via cap-dependent or -independent translation41, including ARUKA, RUNX3, DCK, and PTEN. We found that the protein levels but not mRNA levels of these genes were downregulated in hnRNPQ-depleted cells (Supplementary Fig. 8h, i), suggesting that these hnRNPQ targets might also be associated with gemcitabine-induced cytotoxic effects in tumor cells.