IL22 and inflammatory bowel disease: These findings were replicated in colonic biopsies sampled from an independent cohort of IBD patients with colonic CD and active UC (GSE16879, online supplementary figure 9).32 As well as demonstrating significantly higher expression levels of IL22 responsive transcripts in patients with active colonic IBD, unsupervised hierarchical clustering could fully differentiate CD and UC patients from controls (online supplementary figure 10).