TRUC mice develop chronic microbiota-dependent colitis, mediated by pathogenic group 3 innate lymphoid cells, and disease is alleviated following administration of anti-TNFα or anti-IL23p19 mAbs.14 19 20 Profiling the colonic transcriptome of TRUC mice demonstrated significant enrichment of IL22-responsive transcripts in the colon of TRUC mice. The gene discussed is IL22; the disease is colitis.