After exposure to a regimen of multiple doses of urethane, 6 mo after the first urethane injection mice lacking IKKα (IKKαKO in AT-II lung epithelial cells), in contrast to wild type (WT) IKKα (IKKαWT) control mice, developed a significantly greater number of small (<1 mm size) adenomas and a unique class of much larger tumors (>1 mm in size). The gene discussed is CHUK; the disease is adenoma.