In the urethane-induced NSCLC mouse model, we compared the levels of HIF-1α protein in the small lung adenomas of multiple IKKα WT control IKKα+/+:Sftpc-CreERT2 mice with the amounts of HIF-1α expressed by the unique class of large adenomas in the experimental IKKαf/f:Stpc-CreERT2 mice (Fig 7). Here, HIF1A is linked to lung adenoma.