NFKB1 and non-small cell lung carcinoma: In an inducible transgenic FVB mouse model expressing an IκBαDN (dominant negative) transgene in airway epithelium, urethane-induced lung inflammation was blocked and tumor formation was reduced indicating that canonical NF-κB signaling in airway epithelium is integral to lung tumorigenesis induced by urethane (Stathopoulos et al, 2007) and may be a potential chemopreventive NSCLC target.