Vreka and colleagues reported that IKKα acts as a tumor promoter in K-Ras mutant NSCLC (Vreka et al, 2018), and just before their study, a published report by another group showed that IKKα instead acts as a tumor suppressor in oncogenic K-Ras–induced NSCLC (Song et al, 2018). The gene discussed is CHUK; the disease is non-small cell lung carcinoma.