Importantly, in this context, mutant K-Ras programming leads to inflammation (Ji et al, 2006; Moghaddam et al, 2009; Xia et al, 2012) and enhanced canonical NF-κB activity (Meylan et al, 2009; Basseres et al, 2010; Xia et al, 2012) in mouse NSCLC models. This evidence concerns the gene NFKB1 and non-small cell lung carcinoma.