HIGD2A and lung adenoma: Interestingly, the one up-regulated DEG that is shared in common between the murine IKKαKO large lung adenomas and xenografts of the H1437, A549, and H1299 IKKαKD human NSCLCs is HIGD2A (hypoxia-inducible domain family member 2A) encoding a cytochrome c oxidase complex (complex IV) subunit; HIGD2A is the terminal enzyme in the mitochondrial respiratory chain that is regulated by HIF-1α (Ameri et al, 2013) and has been shown (akin to the related protein HIGD1A) to enhance cell survival under hypoxia (An et al, 2011; Salazar et al, 2019).