In this context, our findings herein have revealed that IKKα functions as a potent tumor growth suppressor in both mouse and human NSCLC in vivo models targeted to murine lung epithelial cells or human epithelial NSCLCs, with or without activating, oncogenic K-Ras or wild-type p53 tumor suppressor genes. This evidence concerns the gene KRAS and non-small cell lung carcinoma.