However, there were few HIF-1α target genes shared amongst the up-regulated DEGs in the absence of IKKα in our mouse urethane NSCLC model versus three unrelated human NSCLCs (H1437, A549, and H1299) grown in vivo as tumor xenografts, in agreement with previously published findings (Benita et al, 2009; Dengler et al, 2014), and thus suggesting that there is potential variability in the HIF-1α target gene signatures of unrelated NSCLC tumors with different activating mutations. This evidence concerns the gene HIF1A and neoplasm.