Taken together, our findings in two independent in vivo models indicate that IKKα in lung epithelial cells functions as a tumor suppressor by reducing murine NSCLC growth and human NSCLC tumor xenograft burden, at least in part, by inhibiting/repressing HIF-1α protein accumulation and the expression of HIF direct target genes. The gene discussed is HIF1A; the disease is non-small cell lung carcinoma.