Multiple RNA-seq experiments were carried out to compare the transcriptomes of: (1) urethane-induced small adenomas in IKKαWT mice versus the unique class of large adenomas in AT-II lung epithelial IKKαKO mice; (2) human H1437, A549, and H1299 NSCLCs with or without IKKα knockdown grown as tumor xenografts in NSG immune-compromised mice. The gene discussed is CHUK; the disease is adenoma.