Moreover, because several studies have indicated that HIF-1α–induced genes may differ in different cell types and cancer cells with diverse mutations (Benita et al, 2009;, Dengler et al, 2014), HIF-1α activation may have led to the activation of different downstream target genes in our two independent NSCLC in vivo models. This evidence concerns the gene HIF1A and non-small cell lung carcinoma.