CHUK and neoplasm: To determine if specific pathways associated with tumor development and growth could be altered in response to the IKKα loss, we used Ingenuity upstream regulator analysis, which infers upstream regulator activation based on differentially expressed transcripts using Ingenuity’s manually curated knowledge base (QIAGEN Inc., https://www.qiagenbio-informatics.com/products/ingenuity-pathway-analysis).