IKBKB and non-small cell lung carcinoma: In accord with these earlier reports, we conclude that the induced ablation of IKKβ in lung AT-II epithelial cells in our urethane-induced NSCLC mouse model blocks the activation of canonical NF-κB signaling in the airway epithelium, which is required for urethane-induced NSCLC development (Stathopoulos et al, 2007; Zaynagetdinov et al, 2012).