The NF-κB TFs are critical regulators of pro-inflammatory/stress-like responses; and their immediate upstream signaling components are aberrantly expressed and/or activated in pulmonary diseases, including NSCLC, and have been implicated in the unfavorable prognosis for patient survival (Greenman et al, 2007; Giopanou et al, 2015). The gene discussed is NFKB1; the disease is non-small cell lung carcinoma.