Comparisons of tumor xenografts obtained with IKKα WT H1437, A549, and H1299 human NSCLC lines and their IKKαKD derivatives along with statistical analyses clearly show that IKKα protein knockdown in each of these three human NSCLC lines significantly increases their tumor burdens in NSG mice (Fig 4A and B). This evidence concerns the gene CHUK and neoplasm.