C9orf72 and amyotrophic lateral sclerosis: To this end, we immunohistochemically investigated circadian sleep/wake-associated cells (i.e. the pineal gland and SCN-related neurons in the hypothalamus) for the presence of ALS- and FTLD-TDP-related pathological protein inclusions (DPRs and phosphorylated TDP-43 (pTDP-43)) in patients with ALS and/or FTLD-TDP with and without the C9orf72 repeat expansion.