Interestingly, the RC-hypermethylated regions were enriched for EGR2 and E2F4 binding sites in a large number of CLL cases (n = 14 and n = 18, respectively); however, most analyzed cases did not show similar enrichment for RC-hypomethylated or EB- (both hyper- and hypomethylated) regions (Additional file 7: Table S6). This evidence concerns the gene EGR2 and B-cell chronic lymphocytic leukemia.