EGFR and B-cell chronic lymphocytic leukemia: Finally, KEGG pathway enrichment analysis based on the DM genes, showed that, in almost all cases, EB-hypomethylated and hypermethylated-regions were enriched for pathways significant for CLL biology, e.g., ErbB, Phospholipase D, Ras, HIF, MAPK, Wnt, T, and B cell receptor, and Notch signaling pathways (Additional file 8: Table S7 and Additional file 9: Table S8).