More specifically, in all cases, the EB-hypomethylated regions showed enrichment for several TFs relevant to B cell/CLL biology, including members of AP-1, GATA, IRF, POU, NFAT, STAT, and TCF families, as well as most members of HOX and FOX development-related TFs. This evidence concerns the gene FOS and B-cell chronic lymphocytic leukemia.