Finally, while conditional cardiac Srsf1 knockout animals die postnatally from defective juvenile-to-adult heart remodeling [18], conditional cardiac knockouts of Srsf2 (SC35) and Srsf4 (Srp75) are viable but develop dilated and hypertrophic cardiomyopathies, respectively [20, 21]. Here, SRSF4 is linked to hypertrophic cardiomyopathy.