To evaluate if EZH2 inhibition in GBM could impact on inflammation, and to gain further insight into the molecular mechanism of MC4040 and MC4041, we investigated on the expression patterns of the main inflammatory and anti-inflammatory cytokines in U-87 and GL1 cells in untreated and in MC4040- and MC4041-treated samples. This evidence concerns the gene EZH2 and glioblastoma.