In the inflammatory subgroup, CRP levels were slightly higher at last visit 13.2 (3–88.6) mg/l compared to first visit 9.5 (3–50.1) mg/l (p = 0.017); no difference was found for non-inflammatory SSc (first visit, 3.2 (2.9–4.0) mg/l; last visit, 3.1 (2.9–4.8) mg/l; p = 0.342). This evidence concerns the gene CRP and systemic sclerosis.