PKM and colorectal carcinoma: To further illustrate the clinical and pathological significance of the LINRIS-IGF2BP2-MYC axis in CRC development, we analyzed 220 samples from the patients described above (Additional file 12: Table S5) by measuring the expression of LINRIS by RNAScope® ISH assays, and that of Ki-67, IGF2BP2, MYC, GLUT-1, PKM2 and LDHA with IHC assays (Fig. 7a).