A part from that, the treatment with 800 mg/kg ethanolic extract of mangosteen pericarp induced protection from atherosclerosis in hypercholestromic rats by maintaining the expression of eNOS (endothelial nitric oxide synthase) and reducing hydrogen peroxide and HIF-1α (hypoxia-inducible factor 1-alpha) that eventually leads to reduce vasa vasorum angiogenesis [13, 59]. Here, NOS3 is linked to atherosclerosis.