TPO and hypothyroidism: However, if adjusting for TPO-abs, the weak association between Tg-abs and hypothyroidism was not significant any more (p > 0.10), while if adjusting for Tg-abs, the association between TPO-abs and hyperthyroidism was still significant (p < 0.001, OR = 18.481, 95%CI = 4.510–75.739).