TPO and hypothyroidism: However, from the perspective of the relationship between antithyroid antibodies and thyroid dysfunction, TPO-abs is more influencing than Tg-abs, since TPO-abs is significantly associated with hyperthyroidism and the association is independent of Tg-abs, but Tg-abs is only marginally significantly associated with hypothyroidism and such association must depend on the presence of TPO-abs, which was consistent with the previous view [64] that Tg-abs alone in the absence of TPO-abs were not usually associated with thyroid dysfunction.