The univariate analyses demonstrated that AFP ≥ 200 ng/ml (hazard ratio [HR], 2.012; 95% CI, 1.088–3.143; p = 0.002), uPA ≥ 1 ng/ml (HR, 1.968; 95% CI, 1.271–3.049; p = 0.002), tumor size > 5 cm (HR, 2.402; 95% CI, 1.515–3.663; p < 0.001), vascular invasion (HR, 3.812; 95% CI, 2.268–6.407; p < 0.001), and pathology stage (III/IV vs. I/II) (HR, 4.980; 95% CI, 3.226–7.687; p < 0.001) were associated with OS. The gene discussed is PLAU; the disease is neoplasm.