When the type 2 diabetes group was stratified by glucose-lowering drug therapy and compared with the group without diabetes, the highest risk was associated with patients prescribed insulin only (IRR for CVD hospitalization, 1.47; 95% CI, 1.34-1.60; IRR for non-CVD hospitalization, 1.68; 95% CI, 1.57-1.80). This evidence concerns the gene INS and type 2 diabetes mellitus.