Compared with patients with probable DLB who did not carry APOE e4, APOE e4 carriers had higher mean (SD) baseline PiB SUVR (1.40 [0.27] vs 1.79 [0.46]; P = .005) and lower mean (SD) UPDRS-III motor score (11.1 [5.5] vs 6.5 [5.7]; P = .02). Here, APOE is linked to Lewy body dementia.