Univariate Cox analyses revealed age, QRS, NYHA functional class III, hemoglobin, BNP, LADs, EDV, ESV, LVEF, GLS, absence of beta-blockers, use of diuretics, diabetes and GFR < 60 ml/min/1.73 m2 as significant predictors of the EVENT. This evidence concerns the gene NPPB and diabetes mellitus.