The RNA-seq data derived from sequencing left ventricular myocardial mRNA libraries obtained from 4 swine of each group show a decrease in the glycolysis related phosphoglycerate mutase in MetS (PGAM1) mRNA (p = 6.2x10-2) and ENO1 (p = 2.7x10-4) in MetS. The gene discussed is ENO1; the disease is metabolic syndrome.