Table 3 shows the lists of top hub genes from the prior network and the final network. As a comparison, STAT1, IRF1, and IRF7 were overlapping genes, suggesting the importance of these well-studied genes in SLE; all three genes were critical in the type I interferon and JAK-STAT pathways [25]. In contrast to the prior network, the final network identified more JAK-STAT pathway genes (JAK2 and STAT2). Here, IRF1 is linked to systemic lupus erythematosus.