To further elucidate the possible mechanisms of intestinal barrier function preservation in HF diet mice and the central role of gut apoptosis in pathophysiology of multiple diseases [16, 17], we evaluated a number of molecular events that play crucial roles in apoptotic signaling pathways, such as cleavage of caspase 3, expression of Bax and Bcl-xl. This evidence concerns the gene BCL2L1 and hydrops fetalis.