In addition to the recognized risk factors of AD, including age, sex, apolipoprotein E4 (APOE Ɛ4) phenotype, and low education level, the influence of metabolic syndrome (Mets) related factors such as hypertension, type 2 diabetes mellitus (T2DM), dyslipidemia on AD has also begun to be emphasized. The gene discussed is APOE; the disease is Alzheimer disease.