TP53 and cancer: However, its functions in cellular detoxification (de Keizer et al., 2011; Salcher et al., 2014), and drug-resistance (Hui et al., 2008; Wilson et al., 2011), maintenance of cancer stem cells (Naka et al., 2010) as well as inhibition of other death-inducers such as TP53 (Rupp et al., 2017) suggest also a tumor-promoting role in certain types of cancer.