FOXO3 and cancer: FOXO transcription factors have been implicated in a plethora of different cellular functions, in cancer immunity where loss of FOXO3 exerts anti-cancer effects, but also hampers other arms of the immune system (Luo and Li, 2018), in neuronal development and plasticity (McLaughlin and Broihier, 2018), cancer angiogenesis and metabolism (Yadav et al., 2018).