FOXO3 and cancer: Thereby, stress induced signaling kinases, such as JNK or MST1 that cause FOXO3 activation and nuclear accumulation also in presence of PKB signaling critically contribute to FOXO3-triggered therapy-resistance programs that protect cancer cells during therapy (Hagenbuchner et al., 2016b; Rupp et al., 2017; Naka et al., 2010).