Such regulation may in turn be modulated by input from the adaptive ISR as it promotes expression of stress‐mitigating genes including Slc7a5. Moreover, Wnt promotion of metabolic gene expression is characteristic of many cancer cell states, for example, β‐catenin‐promoted cMyc expression upregulates glycolytic genes in such contexts 94, supporting the view that multiple Wnt downstream pathways orchestrate cellular metabolism. The gene discussed is SLC7A5; the disease is cancer.