Psoriasis presents variable expressivity according to the genetic component and environmental factors, which could affect other locations such as the oral mucosa.6, 7, 8 The oral lesion most strongly associated with psoriasis is geographic tongue (GT), characterized by irregular areas of loss of filiform papillae, often circumscribed by a yellowish-white line.8, 9, 10 Similar to psoriasis, GT is a chronic inflammatory disease with a genetic and immunological basis that has been described to have also a role of IL-6 and IL-17 in its development.10, 11, 12, 13. Here, IL6 is linked to psoriasis.