Both PBC and SS are characterized by inflammation and immune-mediated destruction of epithelial tissue; moreover, the PDC-E2 target antigen has been identified in both bile duct and salivary gland epithelium, which strongly demonstrates the association between both conditions.2, 5 In addition, the finding that the salivary and lacrimal glands, as well as the urinary tract epithelium, may also be damaged in PBC has led to the hypothesis that PBC, similarly to SS, can be considered a generalized epithelitis.8 The gene discussed is DLAT; the disease is synovial sarcoma.