In addition, mutations in p53 can be found in AKs and squamous cell carcinomas (SCCs) in most cases, and in higher concentrations in SCC, whereas patients without suspected cancer lesions do not express p53 mutations, suggesting that mutations in p53 may be involved in the conversion of AK to SCC, and, consequently, may indicate activity in the field of cutaneous cancer.9 The gene discussed is TP53; the disease is cancer.