SHANK3 and premenstrual tension: PMS is presumed to be a synaptic disorder as the probable disease‐defining gene SHANK3 codes for a synaptic protein of the postsynaptic density.57, 58 The results of the current study suggest an additional involvement of the SHANK3 protein in axonal path finding, fiber bundle integrity, and myelin formation given that we detected an impairment of the fiber integrity.