Since white matter alterations might constitute the link between symptoms of autism spectrum,17 cognitive deficits,18 motor impairment,19 and speech20 and given that structural connectivity analysis might be one way to unravel the in vivo morphological phenotype in autism spectrum disorders,21 we investigated the white matter microstructure in SHANK3‐deficient participants by diffusion tensor imaging (DTI). Here, SHANK3 is linked to Cognitive impairment.