Indeed, there have been some studies in non‐Shank3 autism mouse models45, 46 which demonstrated functional and structural alterations in circuits of the anterior and posterior forebrain.54, 55 A previous study reported largely disrupted functional connectivity and abnormal gray matter anatomy in prefrontal areas of homozygous Shank3 KO mice, associated with socio‐communicative deficits. Here, SHANK3 is linked to autism.