Some studies have shown that aberrant activation of Wnt/β‐catenin in LGR5+/PROM1+/BMI‐1+ CSCs is important for CRC tumorigenesis and tumor progression in murine models (Barker et al., 2009; Sangiorgi and Capecchi, 2008; Yanai et al., 2017; Zhu et al., 2009). This evidence concerns the gene PROM1 and colorectal carcinoma.