Gene expression profiling revealed differential upregulation of MAPK, PI3-K/mTOR, WNT, and JAK/STAT pathway genes in BPL cells from CD22ΔE12-Tg mice closely mimicking the transcriptome of primary leukemia cells from high-risk BPL patients (Accession #GSE58872 and GSE58874) [Figure 1]. This evidence concerns the gene MTOR and leukemia.