In the univariate analysis, statistically significant prognostic factors for poor OS rate included CRP level >0.20 mg/dL, albumin level <3.5 g/dL, AST level >35 IU/L, ICGR15 level >15%, AFP level >10 ng/mL, DCP level >100 mAU/mL, Child‐Pugh grade B, number of tumors >1, tumor size >50 mm, operation time >300 minutes, blood loss >1000 mL, liver cirrhosis, MVI, histological grade well and moderately differentiated, IM, low PNI, high CAR, high GPS, high NLR, and high PI. The gene discussed is AFP; the disease is cirrhosis of liver.