By univariate analysis, eight parameters other than histological stage were significantly associated with disease-free interval (Table 4), i.e., multicentricity, margin status, an inflammatory or anaplastic histological type, tumor-associated inflammation, the histological grade, ER expression, the Ki-67 proliferation index, and the immunophenotype (luminal vs. triple-negative). The gene discussed is ESR1; the disease is neoplasm.