Important work by Klug et al. demonstrated in murine as well as xenotransplanted and human primary tumors that even single low doses of RT ( ≤ 2 Gy) may be capable of reprogramming the tumor microenvironment—in particular polarizing TAMs to an M1 phenotype—causing inducible nitric oxide synthase-mediated vascular normalization, and thus facilitating tumor homing of transferred T-cells (26). Here, NOS2 is linked to neoplasm.