Additional benefits of ICB in the context of RT include: depletion of intratumoral Treg cells (anti-CTLA-4), counteracting RT-induced T-cell exhaustion through upregulation of PD-L1 (anti-PD-(L)1) and a reduction of MDSC populations in the tumor microenvironment (anti-PD-(L)1) (29). The gene discussed is CD274; the disease is neoplasm.