Two recent comprehensive genetic analyses of primary DLBCL also identified a genetic subset of DLBCL characterized by BCL6 structural alterations in combination with mutations of NOTCH pathway components and a low rate of SHM-associated mutations suggesting that the tumors had not transited the GC reaction (Chapuy et al., 2018; Schmitz et al., 2018). Here, BCL6 is linked to diffuse large B-cell lymphoma.