Moreover, though EP300 is able to acetylate BCL6 and repress its recruitment of HDACs (Bereshchenko et al., 2002), EP300 itself is a direct target gene of BCL6 (Cerchietti et al., 2010b) and in primary DLBCL samples, BCL6 and EP300 levels are inversely correlated (Shaknovich and Melnick, 2011). Here, BCL6 is linked to diffuse large B-cell lymphoma.