CXCL8 and angiosarcoma: For example, expression of SNAI2 and its targets, CDH1, VIM, and JUP in hemangiosarcoma cells showed a biphasic response to interkeukin-8 (IL-8), with small amounts of IL-8 favoring self-renewal and abundant IL-8 favoring expansion of bulk (differentiated) tumor cells (8, 16).