Importantly, the HNSCC oncomiR: miR-21 and tumor suppressor miR: miR-29, are both involved in transcriptional networks that regulates the activity of the NF-κB signaling pathway (14, 16), highlighting the importance of NF-κB as a regulator of both inflammation and tumor progression in HNSCC. The gene discussed is NFKB1; the disease is head and neck squamous cell carcinoma.