TOP2A and malignant colon neoplasm: Studies have confirmed that TOP2A is implicated in various types of tumors, such as gastric cancer (Terashima et al., 2017), colon cancer (Hou et al., 2018), pancreatic cancer (Pei, Yin & Liu, 2018) and papillary renal cell carcinoma (Ye et al., 2018).