Although somatic gene mutations, including VHL, BAP-1, PBRM-1, KDM5C, SETD2, and MTOR genes (Chow, Dong & Devesa, 2010; Ricketts et al., 2018) are involved in the pathogenesis of ccRCC, the molecular mechanism of ccRCC is still not fully elucidated. The gene discussed is KDM5C; the disease is nonpapillary renal cell carcinoma.