Although somatic gene mutations, including VHL, BAP-1, PBRM-1, KDM5C, SETD2, and MTOR genes (Chow, Dong & Devesa, 2010; Ricketts et al., 2018) are involved in the pathogenesis of ccRCC, the molecular mechanism of ccRCC is still not fully elucidated. This evidence concerns the gene PBRM1 and nonpapillary renal cell carcinoma.