BDNF and central nervous system disorder: Resistance training for the lower limbs in non-frail and pre-frail 48 elderly women evaluated by Coelho et al. [117] showed increased serum BDNF (BDNF is associated with neuroprotection in a series of central nervous system diseases in older age) concentration after training (before 351±68 pg/ml and after 593±79 pg/ml; p<0.001).