Interestingly, CLRUA and fractional excretion of urate in patients with renal hypouricemia, mainly caused by loss‐of‐function homozygous mutation of SLC22A12/URAT1, increased to 68.3 ± 31.6 mL/min and 0.584 ± 0.264 respectively.23 However, in this study, CLRUA and fractional excretion of urate were 47.9 mL/min and 0.51 respectively. This evidence concerns the gene SLC22A12 and hypouricemia, renal.