On Porto Santo, increasing numbers of T alleles at SNP 5239s1 (estimate = 0.69, SE = 0.27, p = 0.011), and A alleles at SNP TLR4_2 (estimate = 1.03, SE = 0.42, p = 0.016), were associated with increased malaria risk. The gene discussed is TLR4; the disease is malaria.