TLR4 plays a pivotal role in hepatic fat accumulation and NAFLD development, several studies have shown that curcumin administration has been involved in the regulation of different inflammatory cytokines including TNF-α and IL-1β through inhibiting the activation of the TLR4/NF-κB signaling pathways [16, 17]. Here, TLR4 is linked to metabolic dysfunction-associated steatotic liver disease.