High levels of GLI-1 expression is significantly associated with worst overall survival in two independent cohorts of patients [(Shi et al., 2012) and analysis of mesothelioma TCGA (https://portal.gdc.cancer.gov/projects/TCGA-MESO) data using Progene2 (Goswami and Nakshatri 2014)]. The gene discussed is GLI1; the disease is mesothelioma.