Immunologic profiling evidenced marked hypergammaglobulinemia of all isotypes tested (IgG, IgA, IgM) that was associated with moderate CD4+ and CD8+ T lymphocytosis, a low proportion of naïve CD4+ and CD8+ T lymphocytes, a high proportion of CD8+ memory T lymphocytes, and moderate B cell lymphopenia (Table 1). This evidence concerns the gene CD4 and Decreased total B cell count.