We have reported that the axis tmTNF/TNFRs can be self-regulated during BCG-induced pleurisy, tmTNF restores the normal expression of TNFR2 on myeloid cells, and in turn, the absence of TNFR1 affects the expression of TNFR2, leading to exacerbated inflammation and bad control of the infection (32). The gene discussed is TNFRSF1B; the disease is infection.