TP53 and chlamydia trachomatis infectious disease: We further verified the activation of the PI3K/Akt and NF-κB signaling pathways, which may be involved in the pathogenesis of chlamydial infections, based on the expression of PI3K, p-Akt, p53 (a tumor suppressor that can be downregulated by activation of PI3K/Akt pathway), and NF-κB (p65).