Consequently, in vivo treatment of APP/PS1/SREBP-2 mice with the cell-permeable GSH ethyl ester, which restored mGSH levels, attenuated synaptic degeneration and improved cognition, suggesting that therapeutic strategy to prevent mitochondrial cholesterol accumulation or the restoration of mGSH levels may represent a relevant approach in the treatment of AD. The gene discussed is PSEN1; the disease is Alzheimer disease.