SREBF2 and Alzheimer disease: Moreover, APP/PS1/SREBP-2 mice, which exhibit an early mitochondrial cholesterol loading and mGSH depletion, exhibited an accelerated β-secretase activation, Aβ accumulation, and cognitive decline compared to APP/PS1 mice (11), further supporting the correlation between mitochondrial cholesterol accumulation and the subsequent mGSH depletion in AD.