PSEN1 and Alzheimer disease: In the last decade, significant progress has been made on the impact of cholesterol accumulation in mitochondrial function and routine performance in AD and NPC disease using genetic mouse models, such as the APP/PSEN1 transgenic mice overexpressing SREPB-2 (APP/PSEN1/SREBP2) and the Npc1−/− knockout mice (10–14).